Tentative Term Presentation Topics: 1) Comparative genomics and applications 2) Metagenomics and comparative metagenomics 3) Gene regulatory networks and modules 4) Computational approaches for functional genomics 5) RNA secondary structure prediction 6) Small RNAs, microRNAs and other noncoding RNAs 7) Protein secondary structure determination 8) Protein tertiary structure determination (or protein folding), especially recent breakthroughs including AlphaFold/RoseTTAFold/ESMFold Kenny Thai, 5/28 talk 1 9) Protein-protein (or protein-drug) interactions 10) Peptide sequencing/identification by mass spec 11) Molecular dyanmics modeling and simulation Nina Phatak, 6/2 talk 1 12) SNPs and haplotype inference 13) Genome-wide association studies (GWAS) 14) Disease gene prioritization based on networks of genes and diseases 15) Genetic drug discovery and combinatorial chemistry 16) Drug repositioning and repurposing with applications in COVID-19 17) Representation, simulation, and inference of gene networks and pathways 18) Next generation resequencing (NGS) technologies (DNA-Seq, RNA-Seq, ChIP-Seq, DNase-Seq, ATAC-Seq, SHAPE-Seq, CLIP-Seq, etc) on Illumina/Solexa, 454, SOLiD, SMRT, Nanopore, etc. platforms and their data analysis; multiple non-overlapping talks are possible 19) Genome assembly from NGS short reads, de Bruijn graphs 20) Transcriptome assembly and abundance quantification 21) Computational challenges in epigenomics 22) Computational prediction of chromosomal structures using Hi-C, ChIA-PET, etc 23) Spatial (or 4D) genomics 23) Single-cell spatial transcriptomics 25) Integration of multi-omics data 26) The ENCODE project and its key findings/datasets Neda Farahmandi, 5/26 talk 1 27) Analysis of medical (such as CT, MRI, X-ray, etc.) images 28) Genomics and human health, immunotherapy, etc. 29) Evolution of viruses (e.g., SARS-CoV-2) 30) Foundation models in biology and medicine such as AlphaGenome, Evo 2, scGPA, Geneformer, DNABERT, RNABERT, etc. 31) A deeper treatment of some topic covered in class such as the complexity of PDP, gene/exon prediction, sequence assembly, phylogenies, etc; multiple non-overlapping talks are possible 32) An interesting extension/observation/revision on some technical result discussed in class or the textbooks 33) A comparison between combinatorial and statistical approaches for solving the same problem 34) Other interesting topics that I have missed in the above, e.g. applications of well-known data structures, algorithmic techniques and ML/DL models such as suffix trees/arrays, BW/FM transformations, etc. in computational biology; multiple non-overlapping talks are possible Each topic will be presented by a student. Ideally, a presentation should begin with (1) the biological background, (2) an overview of computational problems, (3) a survey of algorithmic approaches for solving the problems, and then (4) some discussion of one or two of the approaches in more depth. Every student should prepare to read 3 to 5 papers, speak for about 22 minutes and answer questions for about 3 minutes at the end of the presentation. The presentations will take place from Thursday May 21 to Thursday June 4 during the regular lecture hours. We can accommodate three speakers in a lecture. Please let me know your preferred presentation topic and date ASAP. Remember that the earlier you choose, the more choices you will have :-) Note that you are supposed to create your own slides for the presentation, but if you have to borrow some material from somewhere (e.g., figures, tables, or sometimes entire slides), you must cite the sources (including AI) explicitly.